Publications

  • McDonnell CJ, Soule EE, Walsh PT, O’Donnell JS, Preston RJS. The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease. Semin Thromb Hemost. 2017 Dec 12. doi: 10.1055/s-0037-1608910. PubMed PMID: 29232721.

 

  • Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O’Sullivan JM, O’Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, Preston RJS, Budde U, James P, Di Paola J, O’Donnell JS. Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels. Blood. 2017 Sep 15. pii:blood-2017-05-786699. doi: 10.1182/blood-2017-05-786699. [Epub ahead of print] PubMed PMID: 28916584.

 

  • Gleeson EM, McDonnell CJ, Soule EE, Willis Fox O, Rushe H, Rehill A, Smith OP, O’Donnell JS, Preston RJS. A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective protease-activated receptor 1 signaling. J Thromb Haemost. 2017 Aug 20. doi: 10.1111/jth.13807. [Epub ahead of print] PubMed PMID: 28834159.

 

  • Preston RJS, O’Donnell JS. Microbiome influences von Willebrand factor. Blood. 2017 Jul 27;130(4):393-395. doi: 10.1182/blood-2017-06-789156. PubMed PMID: 28751359.

 

  • Chion A, O’Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S,Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O’Donnell JS. N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance. Blood. 2016 Oct 13;128(15):1959-1968. Epub 2016 Aug 23. PubMed PMID: 27554083.

 

  • O’Sullivan JM, Jenkins PV, Rawley O, Gegenbauer K, Chion A, Lavin M, Byrne B, O’Kennedy R, Preston RJ, Brophy TM, O’Donnell JS. Galectin-1 and Galectin-3 Constitute Novel-Binding Partners for Factor VIII. Arterioscler Thromb Vasc Biol. 2016 May;36(5):855-63. doi: 10.1161/ATVBAHA.115.306915. Epub 2016 Mar 24. PubMed PMID: 27013611.

 

  • Heurich M, Preston RJ, O’Donnell VB, Morgan BP, Collins PW. Thrombomodulin enhances complement regulation through strong affinity interactions with factor Hand C3b-Factor H complex. Thromb Res. 2016 Sep;145:84-92. doi:10.1016/j.thromres.2016.07.017. Epub 2016 Aug 2. PubMed PMID: 27513882.

 

  • O’Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O’Donnell JS. N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor. J Thromb Haemost. 2016 Dec;14(12):2446-2457. doi: 10.1111/jth.13537. Epub 2016 Dec 9. PubMed PMID: 27732771.

 

  • O’Sullivan JM, Preston RJ (joint first author), O’Regan N, O’Donnell JS. Emerging roles for hemostatic dysfunction in malaria pathogenesis. Blood. 2016 May 12;127(19):2281-8. doi: 10.1182/blood-2015-11-636464. Epub 2016 Feb 5. Review. PubMed PMID: 26851291.

 

  • O’Regan N, Moxon C, Gegenbauer K, O’Sullivan JM, Chion A, Smith OP, Preston RJ, Brophy TM, Craig AG, O’Donnell JS. Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria. Thromb Haemost. 2016 Apr;115(4):773-80. doi: 10.1160/TH15-10-0796. Epub 2016 Jan 14. PubMed PMID: 26766771; PubMed Central PMCID: PMC4990170.

 

  • Quinn LM, Drakeford C, O’Donnell JS, Preston RJ. Engineering activated protein C to maximize therapeutic efficacy. Biochem Soc Trans. 2015 Aug;43(4):691-5. doi: 10.1042/BST20140312. Epub 2015 Aug 3. Review. PubMed PMID: 26551714.

 

  • O’Regan N, Gegenbauer K, O’Sullivan JM, Maleki S, Brophy TM, Dalton N, Chion A, Fallon PG, Grau GE, Budde U, Smith OP, Craig AG, Preston RJ, O’Donnell JS. A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood. 2016 Mar 3;127(9):1192-201. doi: 10.1182/blood-2015-07-654921. Epub 2015 Oct 28. PubMed PMID: 26511133; PubMed Central PMCID: PMC4815815.

 

  • Hams E, Bermingham R, Wurlod FA, Hogan AE, O’Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG. The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism. FASEB J. 2016 Feb;30(2):824-35. doi: 10.1096/fj.15-277822. Epub 2015 Oct 21. PubMed PMID: 26490658; PubMed Central PMCID: PMC4973506.

 

  • Gleeson EM, Dichiara MG, Salicio A, Quinn LM, Drakeford C, Russell SE, Walsh PT, Orbe J, Hermida J, Smith OP, O’Donnell JS, Montes R, Preston RJ. Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury. Blood. 2015 Aug 13;126(7):915-9. doi: 10.1182/blood-2015-03-632877. Epub 2015 Jun 17. PubMed PMID: 26084674.

 

  • Rawley O, O’Sullivan JM, Chion A, Keyes S, Lavin M, van Rooijen N, Brophy TM, Fallon P, Preston RJ, O’Donnell JS. von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo. J. Thromb Haemost. 2015 May;13(5):821-6. doi: 10.1111/jth.12875. Epub 2015 Apr 13. PubMed PMID: 25690668.

 

  • Eliwan HO, Watson RW, Aslam S, Regan I, Philbin B, O’Hare FM, O’Neill A, Preston RJ, Blanco A, Grant T, Nolan B, Smith O, Molloy EJ. Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo. Clin Exp Immunol. 2015 Mar;179(3):477-84. doi: 10.1111/cei.12453. PubMed PMID: 25204207; PubMed Central PMCID: PMC4337680.

 

  • Kevane B, Donnelly J, D’Alton M, Cooley S, Preston RJ, Ní Ainle F. Risk factors for pregnancy-associated venous thromboembolism: a review. J Perinat Med. 2014 Jul;42(4):417-25. doi: 10.1515/jpm-2013-0207. Review. PubMed PMID: 24334422.

 

  • McGrath RT, van den Biggelaar M, Byrne B, O’Sullivan JM, Rawley O, O’Kennedy R, Voorberg J, Preston RJ, O’Donnell JS. Altered glycosylation of platelet-derived von Willebrand factor confers resistance to ADAMTS13 proteolysis. Blood. 2013 Dec 12;122(25):4107-10. doi: 10.1182/blood-2013-04-496851. Epub 2013 Oct 8. PubMed PMID: 24106205.

 

  • Gleeson EM, O’Donnell JS, Hams E, Ní Áinle F, Kenny BA, Fallon PG, Preston RJ. Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells. Haematologica. 2014 Jan;99(1):185-93. doi:10.3324/haematol.2013.086918. Epub 2013 Jul 19.

 

  • Preston RJ, Rawley O, Gleeson EM, O’Donnell JS. Elucidating the role of carbohydrate determinants in regulating hemostasis: insights and opportunities. Blood. 2013 May 9;121(19):3801-10. doi:10.1182/blood-2012-10-415000. Epub 2013 Feb 20. Review. PubMed PMID: 23426946.

 

  • Gleeson EM, O’Donnell JS, Preston RJ. The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling. Cell Mol Life Sci. 2012 Mar;69(5):717-26. doi:10.1007/s00018-011-0825-0. Epub 2011 Oct 4. Review. PubMed PMID: 21968919.

 

  • Ní Ainle F, O’Donnell JS, Johnson JA, Brown L, Gleeson EM, Smith OP, Preston RJ Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol Chem. 2011 Jan 14;286(2):1323-30. doi: 10.1074/jbc.M110.159475. Epub 2010 Nov 2. PubMed PMID: 21044954; PubMed Central PMCID: PMC3020740.

 

  • McGrath RT, McKinnon TA, Byrne B, O’Kennedy R, Terraube V, McRae E, Preston RJ, Laffan MA, O’Donnell JS. Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13. Blood. 2010 Apr 1;115(13):2666-73. doi: 10.1182/blood-2009-09-241547. Epub 2009 Nov 24. PubMed PMID: 19965639.

 

  • Bridges DJ, Bunn J, van Mourik JA, Grau G, Preston RJ, Molyneux M, Combes V, O’Donnell JS, de Laat B, Craig A. Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. Blood. 2010 Feb 18;115(7):1472-4. doi: 10.1182/blood-2009-07-235150. Epub 2009 Nov 6. PubMed PMID: 19897581; PubMed Central PMCID: PMC2840836.

 

  • Ni Ainle F, Preston RJ, Jenkins PV, Nel HJ, Johnson JA, Smith OP, White B, Fallon PG, O’Donnell JS. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood. 2009 Aug 20;114(8):1658-65. doi: 10.1182/blood-2009-05-222109. Epub 2009 Jun 16. PubMed PMID: 19531655.

 

  • Larkin D, de Laat B, Jenkins PV, Bunn J, Craig AG, Terraube V, Preston RJ, Donkor C, Grau GE, van Mourik JA, O’Donnell JS. Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathog. 2009 Mar;5(3):e1000349. doi:10.1371/journal.ppat.1000349. Epub 2009 Mar 20. PubMed PMID: 19300493; PubMed Central PMCID: PMC2652105.

 

  • Preston RJ, Morse C, Murden SL, Brady SK, O’Donnell JS, Mumford AD. The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity. Br J Haematol. 2009 Mar;144(6):946-53. doi: 10.1111/j.1365-2141.2008.07550. Epub 2008 Dec 26. PubMed PMID: 19133979.

 

  • Preston RJ, Tran S, Johnson JA, Ní Áinle F, Harmon S, White B, Smith OP, Jenkins PV, Dahlbäck B, O’Donnell JS. Platelet factor 4 impairs the anticoagulant activity of activated protein C. J Biol Chem. 2009 Feb 27;284(9):5869-75. doi: 10.1074/jbc.M804703200. Epub 2009 Jan 6. PubMed PMID: 19129181.

 

  • Cunningham MS, Preston RJ, O’Donnell JS. Does antithrombotic therapy improve survival in cancer patients? Blood Rev. 2009 May;23(3):129-35. doi: 10.1016/j.blre.2008.10.002. Epub 2008 Nov 28. Review. PubMed PMID: 19046797.

 

  • Harmon S, Preston RJ (joint first author), Ni Ainle F, Johnson JA, Cunningham MS, Smith OP, White B, O’Donnell JS. Dissociation of activated protein C functions by elimination of protein S cofactor enhancement. J Biol Chem. 2008 Nov 7;283(45):30531-9. doi:10.1074/jbc.M802338200. Epub 2008 Sep 8. PubMed PMID: 18779332; PubMed Central PMCID: PMC2662146.

 

  • Hochart H, Jenkins PV, Preston RJ, Smith OP, White B, O’Donnell J. Concentration-dependent roles for heparin in modifying lipopolysaccharide-induced activation of mononuclear cells in whole blood. Thromb Haemost. 2008 Mar;99(3):570-5. doi: 10.1160/TH07-06-0424. PubMed PMID: 18327406.

 

  • Persson KE, Stenflo J, Linse S, Stenberg Y, Preston RJ, Lane DA, Rezende SM. Binding of calcium to anticoagulant protein S: role of the fourth EGF module. Biochemistry. 2006 Sep 5;45(35):10682-9. PubMed PMID: 16939220; PubMed Central PMCID: PMC2242855.

 

  • Preston RJ, Ajzner E, Razzari C, Karageorgi S, Dua S, Dahlbäck B, Lane DA. Multifunctional specificity of the protein C/activated protein C Gla domain. Biol Chem. 2006 Sep 29;281(39):28850-7. Epub 2006 Jul 25. PubMed PMID: 16867987.

 

  • Mollica L, Preston RJ, Chion AC, Lees SJ, Collins P, Lewis S, Lane DA. Autoantibodies to thrombin directed against both of its cryptic exosites. Br J Haematol. 2006 Feb;132(4):487-93. PubMed PMID: 16412021.

 

  • Zanardelli S, Crawley JT, Chion CK, Lam JK, Preston RJ, Lane DA. ADAMTS13 substrate recognition of von Willebrand factor A2 domain. J Biol Chem. 2006 Jan 20;281(3):1555-63. Epub 2005 Oct 12. PubMed PMID: 16221672.

 

  • Biguzzi E, Razzari C, Lane DA, Castaman G, Cappellari A, Bucciarelli P, Fontana G, Margaglione M, D’Andrea G, Simmonds RE, Rezende SM, Preston R, Prisco D, Faioni EM; Protein S Italian Team. Molecular diversity and thrombotic risk in protein S deficiency: the PROSIT study. Hum Mutat. 2005 Mar;25(3):259-69. PubMed PMID: 15712227.

 

  • Preston RJ, Villegas-Mendez A, Sun YH, Hermida J, Simioni P, Philippou H, Dahlbäck B, Lane DA. Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation. FEBS J. 2005 Jan;272(1):97-108. PubMed PMID: 15634335.